Neurotransmitter and Hormone Receptors

Facilitation of Neurotransmitter and Hormone Release by P2X Purinergic Receptors

Anti-idiotypic antibodies against hormone and neurotransmitter receptors.

Introduction Hormones, neurotransmitters, even viruses, exert their effects through specific receptors, most often membrane proteins. Molecular characterization of these receptors has been for years an attractive challenge for pharmacologists and the production of specific anti-receptor antibodies has appeared as a way towards this goal. Several polyclonal or monoclonal antibodies have been pre...

Synaptic neurotransmitter-gated receptors.

Since the discovery of the major excitatory and inhibitory neurotransmitters and their receptors in the brain, many have deliberated over their likely structures and how these may relate to function. This was initially satisfied by the determination of the first amino acid sequences of the Cys-loop receptors that recognized acetylcholine, serotonin, GABA, and glycine, followed later by similar ...

Neurotransmitter receptors on microglia

As the resident immune cells in the central nervous system, microglia have long been hypothesised to promote neuroinflammation and exacerbate neurotoxicity. However, this traditional view has undergone recent revision as evidence has accumulated that microglia exert beneficial and detrimental effects depending on activation status, polarisation phenotype and cellular context. A variety of neuro...

Norepinephrine: hormone and neurotransmitter in man.

To determine whether norepinephrine could subserve a hormonal as well as a neurotransmitter function, norepinephrine was infused for 60 min into each of five normal young men in doses of 0.1, 0.5, 1.0, 2.5, and 5.0 microgram/min. After infusion, the plasma norepinephrine concentration fell with a mean (+/-SD) half-time of 2.4 +/- 0.7 min. The mean (+/-SD) norepinephrine metabolic clearance rate...